Wayne Mascarella
Wayne Mascarella
Research Triangle Institute
Verified email at rti.org
Title
Cited by
Cited by
Year
Structure of the human κ-opioid receptor in complex with JDTic
H Wu, D Wacker, M Mileni, V Katritch, GW Han, E Vardy, W Liu, ...
Nature 485 (7398), 327-332, 2012
8662012
Designer drugs: a medicinal chemistry perspective
FI Carroll, AH Lewin, SW Mascarella, HH Seltzman, PA Reddy
Annals of the New York Academy of Sciences 1248 (1), 18-38, 2012
1472012
Synthesis, Ligand Binding, and QSAR (CoMFA and Classical) Study of 3. beta.-(3'-Substituted phenyl)-, 3. beta.-(4'-Substituted phenyl)-, and 3. beta.-(3', 4'-Disubstituted …
FI Carroll, SW Mascarella, MA Kuzemko, Y Gao, P Abraham, AH Lewin, ...
Journal of medicinal chemistry 37 (18), 2865-2873, 1994
1211994
Identification of the first trans-(3 R, 4 R)-dimethyl-4-(3-hydroxyphenyl) piperidine derivative to possess highly potent and selective opioid κ receptor antagonist activity
JB Thomas, RN Atkinson, RB Rothman, SE Fix, SW Mascarella, ...
Journal of medicinal chemistry 44 (17), 2687-2690, 2001
1192001
Kappa opioid receptor ligands
FI Carroll, JB Thomas, SW Mascarella
US Patent 6,559,159, 2003
1152003
Structure− activity analysis of anandamide analogs: relationship to a cannabinoid pharmacophore
BF Thomas, IB Adams, SW Mascarella, BR Martin, RK Razdan
Journal of medicinal chemistry 39 (2), 471-479, 1996
1131996
A comparison of (−)-deoxybenzomorphans devoid of opiate activity with their dextrorotatory phenolic counterparts suggests role of σ2 receptors in motor function
JM Walker, WD Bowen, SL Patrick, WE Williams, SW Mascarella, X Bai, ...
European journal of pharmacology 231 (1), 61-68, 1993
991993
Identification of (3 R)-7-Hydroxy-N-((1 S)-1-{[(3 R, 4 R)-4-(3-hydroxyphenyl)-3, 4-dimethyl-1-piperidinyl] methyl}-2-methylpropyl)-1, 2, 3, 4-tetrahydro-3 …
JB Thomas, RN Atkinson, NA Vinson, JL Catanzaro, CL Perretta, SE Fix, ...
Journal of medicinal chemistry 46 (14), 3127-3137, 2003
932003
Intramolecular photocycloaddition-cyclobutane fragmentation: total synthesis of (.+-.)-silphinene
MT Crimmins, SW Mascarella
Journal Of The American Chemical Society 108 (12), 3435-3438, 1986
84*1986
Enantiomeric N-substituted N-normetazocines: a comparative study of affinities at. sigma., PCP, and. mu. opioid receptors
FI Carroll, P Abraham, K Parham, X Bai, X Zhang, GA Brine, ...
Journal of medicinal chemistry 35 (15), 2812-2818, 1992
771992
Identification of an opioid κ receptor subtype-selective N-substituent for (+)-(3 R, 4 R)-dimethyl-4-(3-hydroxyphenyl) piperidine
JB Thomas, MJ Fall, JB Cooper, RB Rothman, SW Mascarella, H Xu, ...
Journal of medicinal chemistry 41 (26), 5188-5197, 1998
751998
Emergence and properties of spice and bath salts: a medicinal chemistry perspective
AH Lewin, HH Seltzman, FI Carroll, SW Mascarella, PA Reddy
Life sciences 97 (1), 9-19, 2014
732014
Synthesis, ligand binding, and quantitative structure− activity relationship study of 3β-(4 ‘-substituted phenyl)-2β-heterocyclic tropanes: evidence for an electrostatic …
P Kotian, SW Mascarella, P Abraham, AH Lewin, JW Boja, MJ Kuhar, ...
Journal of medicinal chemistry 39 (14), 2753-2763, 1996
701996
Dopamine-transporter uptake blockers
FI Carroll, AH Lewin, SW Mascarella
Neurotransmitter Transporters, 381-432, 2002
682002
Investigation of the N-Substituent Conformation Governing Potency and μ Receptor Subtype-Selectivity in (+)-(3 R, 4 R)-Dimethyl-4-(3-hydroxyphenyl)-piperidine Opioid Antagonists
JB Thomas, SW Mascarella, RB Rothman, JS Partilla, H Xu, ...
Journal of medicinal chemistry 41 (11), 1980-1990, 1998
651998
Bupropion and bupropion analogs as treatments for CNS disorders
FI Carroll, BE Blough, SW Mascarella, HA Navarro, RJ Lukas, MI Damaj
Advances in pharmacology 69, 177-216, 2014
612014
Hydrolytic instability of the important orexin 1 receptor antagonist SB-334867: possible confounding effects on in vivo and in vitro studies
CJ McElhinny Jr, AH Lewin, SW Mascarella, S Runyon, L Brieaddy, ...
Bioorganic & medicinal chemistry letters 22 (21), 6661-6664, 2012
542012
Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation
FI Carroll, BE Blough, SW Mascarella, HA Navarro, JB Eaton, RJ Lukas, ...
Journal of medicinal chemistry 53 (5), 2204-2214, 2010
502010
Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation
RJ Lukas, AZ Muresan, MI Damaj, BE Blough, X Huang, HA Navarro, ...
Journal of medicinal chemistry 53 (12), 4731-4748, 2010
482010
N-Substituted 9β-methyl-5-(3-hydroxyphenyl) morphans are opioid receptor pure antagonists
JB Thomas, X Zheng, SW Mascarella, RB Rothman, CM Dersch, ...
Journal of medicinal chemistry 41 (21), 4143-4149, 1998
461998
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