Discovery of dabrafenib: a selective inhibitor of Raf kinases with antitumor activity against B-Raf-driven tumors TR Rheault, JC Stellwagen, GM Adjabeng, KR Hornberger, KG Petrov, ... ACS medicinal chemistry letters 4 (3), 358-362, 2013 | 205 | 2013 |
3-(1, 1-Dioxo-2 H-(1, 2, 4)-benzothiadiazin-3-yl)-4-hydroxy-2 (1 H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase R Tedesco, AN Shaw, R Bambal, D Chai, NO Concha, MG Darcy, ... Journal of medicinal chemistry 49 (3), 971-983, 2006 | 196 | 2006 |
Abstract B88: A selective Raf kinase inhibitor induces cell death and tumor regression of human cancer cell lines encoding B‐RafV600E mutation S Laquerre, M Arnone, K Moss, J Yang, K Fisher, LS Kane‐Carson, ... Molecular Cancer Therapeutics 8 (12_Supplement), B88-B88, 2009 | 68 | 2009 |
Preclinical drug metabolism and pharmacokinetic evaluation of GW844520, a novel anti‐malarial mitochondrial electron transport inhibitor H Xiang, J McSurdy‐Freed, GS Moorthy, E Hugger, R Bambal, C Han, ... Journal of pharmaceutical sciences 95 (12), 2657-2672, 2006 | 63 | 2006 |
Interaction of macrolide antibiotics with intestinally expressed human and rat organic anion-transporting polypeptides T Lan, A Rao, J Haywood, CB Davis, C Han, E Garver, PA Dawson Drug metabolism and disposition 37 (12), 2375-2382, 2009 | 55 | 2009 |
Involvement of intestinal uptake transporters in the absorption of azithromycin and clarithromycin in the rat E Garver, ED Hugger, SP Shearn, A Rao, PA Dawson, CB Davis, C Han Drug metabolism and disposition 36 (12), 2492-2498, 2008 | 49 | 2008 |
AAPS workshop report: strategies to address therapeutic protein–drug interactions during clinical development S Girish, SW Martin, MC Peterson, LK Zhang, H Zhao, J Balthasar, ... The AAPS journal 13, 405-416, 2011 | 47 | 2011 |
Concomitant oral and intravenous pharmacokinetics of dabrafenib, a BRAF inhibitor, in patients with BRAF V600 mutation‐positive solid tumors CL Denton, E Minthorn, SW Carson, GC Young, LE Richards‐Peterson, ... The Journal of Clinical Pharmacology 53 (9), 955-961, 2013 | 42 | 2013 |
Nitric oxide mediates hepatic arterial vascular escape from norepinephrine-induced constriction Z Ming, C Han, WW Lautt American Journal of Physiology-Gastrointestinal and Liver Physiology 277 (6 …, 1999 | 39 | 1999 |
Correlation of the response to nitroglycerin in rabbit aorta with the activity of the mu class glutathione S-transferase SR Kenkare, C Han, LZ Benet Biochemical pharmacology 48 (12), 2231-2235, 1994 | 33 | 1994 |
Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup JC Stellwagen, GM Adjabeng, MR Arnone, SH Dickerson, C Han, ... Bioorganic & medicinal chemistry letters 21 (15), 4436-4440, 2011 | 31 | 2011 |
Evaluation of drug candidates for preclinical development: pharmacokinetics, metabolism, pharmaceutics, and toxicology C Han, CB Davis, B Wang John Wiley & Sons, 2010 | 30 | 2010 |
Factors that impact the developability of drug candidates: an overview C Han, B Wang Drug delivery: principles and applications, 1-14, 2005 | 30 | 2005 |
De-risking bio-therapeutics for possible drug interactions using cryopreserved human hepatocytes S Dallas, C Sensenhauser, A Batheja, M Singer, M Markowska, ... Current drug metabolism 13 (7), 923-929, 2012 | 29 | 2012 |
Pharmacokinetics and brain penetration of casopitant, a potent and selective neurokinin-1 receptor antagonist, in the ferret E Minthorn, T Mencken, AG King, A Shu, D Rominger, RR Gontarek, ... Drug metabolism and disposition 36 (9), 1846-1852, 2008 | 27 | 2008 |
High‐throughput analysis in drug discovery: application of liquid chromatography/ion‐trap mass spectrometry for simultaneous cassette analysis of α‐1a antagonists and their … Z Cai, C Han, S Harrelson, E Fung, AK Sinhababu Rapid Communications in Mass Spectrometry 15 (8), 546-550, 2001 | 23 | 2001 |
Modification of the Fc Region of a human anti‐oncostatin M monoclonal antibody for higher affinity to FcRn receptor and extension of half‐life in cynomolgus monkeys IP Nnane, C Han, Q Jiao, SH Tam, HM Davis, Z Xu Basic & clinical pharmacology & toxicology 121 (1), 13-21, 2017 | 18 | 2017 |
Monoclonal antibodies: interspecies scaling with minimal preclinical information C Han, H Zhou Therapeutic Delivery 2 (3), 359-368, 2011 | 14 | 2011 |
Nitric oxide inhibits norepinephrine-induced hepatic vascular responses but potentiates hepatic glucose output Z Ming, C Han, WW Lautt Canadian journal of physiology and pharmacology 78 (1), 36-44, 1999 | 14 | 1999 |
Improved gas chromatographic assay for the simultaneous determination of nitroglycerin and its mono-and dinitrate metabolites C Han, M Gumbleton, DTW Lau, LZ Benet Journal of Chromatography B: Biomedical Sciences and Applications 579 (2 …, 1992 | 14 | 1992 |