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Chao Han
Chao Han
Tavotek Biotherapeutics
Verified email at tavotek.com
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Cited by
Cited by
Year
Discovery of dabrafenib: a selective inhibitor of Raf kinases with antitumor activity against B-Raf-driven tumors
TR Rheault, JC Stellwagen, GM Adjabeng, KR Hornberger, KG Petrov, ...
ACS medicinal chemistry letters 4 (3), 358-362, 2013
2052013
3-(1, 1-Dioxo-2 H-(1, 2, 4)-benzothiadiazin-3-yl)-4-hydroxy-2 (1 H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase
R Tedesco, AN Shaw, R Bambal, D Chai, NO Concha, MG Darcy, ...
Journal of medicinal chemistry 49 (3), 971-983, 2006
1962006
Abstract B88: A selective Raf kinase inhibitor induces cell death and tumor regression of human cancer cell lines encoding B‐RafV600E mutation
S Laquerre, M Arnone, K Moss, J Yang, K Fisher, LS Kane‐Carson, ...
Molecular Cancer Therapeutics 8 (12_Supplement), B88-B88, 2009
682009
Preclinical drug metabolism and pharmacokinetic evaluation of GW844520, a novel anti‐malarial mitochondrial electron transport inhibitor
H Xiang, J McSurdy‐Freed, GS Moorthy, E Hugger, R Bambal, C Han, ...
Journal of pharmaceutical sciences 95 (12), 2657-2672, 2006
632006
Interaction of macrolide antibiotics with intestinally expressed human and rat organic anion-transporting polypeptides
T Lan, A Rao, J Haywood, CB Davis, C Han, E Garver, PA Dawson
Drug metabolism and disposition 37 (12), 2375-2382, 2009
552009
Involvement of intestinal uptake transporters in the absorption of azithromycin and clarithromycin in the rat
E Garver, ED Hugger, SP Shearn, A Rao, PA Dawson, CB Davis, C Han
Drug metabolism and disposition 36 (12), 2492-2498, 2008
492008
AAPS workshop report: strategies to address therapeutic protein–drug interactions during clinical development
S Girish, SW Martin, MC Peterson, LK Zhang, H Zhao, J Balthasar, ...
The AAPS journal 13, 405-416, 2011
472011
Concomitant oral and intravenous pharmacokinetics of dabrafenib, a BRAF inhibitor, in patients with BRAF V600 mutation‐positive solid tumors
CL Denton, E Minthorn, SW Carson, GC Young, LE Richards‐Peterson, ...
The Journal of Clinical Pharmacology 53 (9), 955-961, 2013
422013
Nitric oxide mediates hepatic arterial vascular escape from norepinephrine-induced constriction
Z Ming, C Han, WW Lautt
American Journal of Physiology-Gastrointestinal and Liver Physiology 277 (6 …, 1999
391999
Correlation of the response to nitroglycerin in rabbit aorta with the activity of the mu class glutathione S-transferase
SR Kenkare, C Han, LZ Benet
Biochemical pharmacology 48 (12), 2231-2235, 1994
331994
Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup
JC Stellwagen, GM Adjabeng, MR Arnone, SH Dickerson, C Han, ...
Bioorganic & medicinal chemistry letters 21 (15), 4436-4440, 2011
312011
Evaluation of drug candidates for preclinical development: pharmacokinetics, metabolism, pharmaceutics, and toxicology
C Han, CB Davis, B Wang
John Wiley & Sons, 2010
302010
Factors that impact the developability of drug candidates: an overview
C Han, B Wang
Drug delivery: principles and applications, 1-14, 2005
302005
De-risking bio-therapeutics for possible drug interactions using cryopreserved human hepatocytes
S Dallas, C Sensenhauser, A Batheja, M Singer, M Markowska, ...
Current drug metabolism 13 (7), 923-929, 2012
292012
Pharmacokinetics and brain penetration of casopitant, a potent and selective neurokinin-1 receptor antagonist, in the ferret
E Minthorn, T Mencken, AG King, A Shu, D Rominger, RR Gontarek, ...
Drug metabolism and disposition 36 (9), 1846-1852, 2008
272008
High‐throughput analysis in drug discovery: application of liquid chromatography/ion‐trap mass spectrometry for simultaneous cassette analysis of α‐1a antagonists and their …
Z Cai, C Han, S Harrelson, E Fung, AK Sinhababu
Rapid Communications in Mass Spectrometry 15 (8), 546-550, 2001
232001
Modification of the Fc Region of a human anti‐oncostatin M monoclonal antibody for higher affinity to FcRn receptor and extension of half‐life in cynomolgus monkeys
IP Nnane, C Han, Q Jiao, SH Tam, HM Davis, Z Xu
Basic & clinical pharmacology & toxicology 121 (1), 13-21, 2017
182017
Monoclonal antibodies: interspecies scaling with minimal preclinical information
C Han, H Zhou
Therapeutic Delivery 2 (3), 359-368, 2011
142011
Nitric oxide inhibits norepinephrine-induced hepatic vascular responses but potentiates hepatic glucose output
Z Ming, C Han, WW Lautt
Canadian journal of physiology and pharmacology 78 (1), 36-44, 1999
141999
Improved gas chromatographic assay for the simultaneous determination of nitroglycerin and its mono-and dinitrate metabolites
C Han, M Gumbleton, DTW Lau, LZ Benet
Journal of Chromatography B: Biomedical Sciences and Applications 579 (2 …, 1992
141992
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