High‐end pH‐controlled delivery of glucose effectively suppresses lactate accumulation in CHO fed‐batch cultures M Gagnon, G Hiller, YT Luan, A Kittredge, J DeFelice, D Drapeau Biotechnology and bioengineering 108 (6), 1328-1337, 2011 | 186 | 2011 |
Adaptation of mammalian cells to growth in serum-free media MS Sinacore, D Drapeau, SR Adamson Molecular biotechnology 15, 249-257, 2000 | 176 | 2000 |
Spin filter perfusion system for high density cell culture: production of recombinant urinary type plasminogen activator in CHO cells GC Avgerinos, D Drapeau, JS Socolow, J Mao, K Hsiao, RJ Broeze Bio/technology 8 (1), 54-58, 1990 | 139 | 1990 |
Growth kinetics of Dioscorea deltoidea and Catharanthus roseus in batch culture D Drapeau, HW Blanch, CR Wilke Biotechnology and bioengineering 28 (10), 1555-1563, 1986 | 120 | 1986 |
The manufacturing process for recombinant factor IX. S Harrison, S Adamson, D Bonam, S Brodeur, T Charlebois, B Clancy, ... Seminars in hematology 35 (2 Suppl 2), 4-10, 1998 | 117 | 1998 |
Generic R aman‐based calibration models enabling real‐time monitoring of cell culture bioreactors H Mehdizadeh, D Lauri, KM Karry, M Moshgbar, R Procopio‐Melino, ... Biotechnology progress 31 (4), 1004-1013, 2015 | 113 | 2015 |
Use of copper and glutamate in cell culture for production of polypeptides D Drapeau, J Snow, G Hiller, YT Luan US Patent 9,012,180, 2015 | 80 | 2015 |
In‐line monitoring of amino acids in mammalian cell cultures using raman spectroscopy and multivariate chemometrics models H Bhatia, H Mehdizadeh, D Drapeau, S Yoon Engineering in Life Sciences 18 (1), 55-61, 2018 | 78 | 2018 |
Restricted glucose feed for animal cell culture YT Luan, TC Stanek, D Drapeau US Patent 7,429,491, 2008 | 75 | 2008 |
Economic assessment of plant cell culture for the production of ajmalicine D Drapeau, HW Blanch, CR Wilke Biotechnology and bioengineering 30 (8), 946-953, 1987 | 68 | 1987 |
Production of anti-abeta D Drapeau, YT Luan, JR Mercer, W Wang, DR Lasko US Patent 7,335,491, 2008 | 51 | 2008 |
Methods of protein production using anti-senescence compounds D Drapeau, YT Luan, P Thoday, W Wang, J Chou US Patent App. 11/585,607, 2007 | 49 | 2007 |
Pharmacokinetics of recombinant factor IX after intravenous and subcutaneous administration in dogs and cynomolgus monkeys K McCarthy, P Stewart, J Sigman, M Read, JC Keith Jr, KM Brinkhous, ... Thrombosis and haemostasis 87 (05), 824-830, 2002 | 49 | 2002 |
Production of polypeptides D Drapeau, YT Luan, JR Mercer, W Wang, DR Lasko US Patent 7,294,484, 2007 | 42 | 2007 |
Improvement of diosgenin yield from Dioscorea deltoidea plant cell cultures by use of a non-traditional hydrolysis method D Drapeau, Y Sauvaire, HW Blanch, CR Wilke Planta medica 52 (06), 474-478, 1986 | 42 | 1986 |
Ajmalicine, serpentine, and catharanthine accumulation in Catharanthus roseus bioreactor cultures D Drapeau, HW Blanch, CR Wilke Planta medica 53 (04), 373-376, 1987 | 41 | 1987 |
Cell culture scale-up in stirred tank reactors D Drapeau, YT Luan, JC Whiteford, DP Lavin, SR Adamson Annual Meeting of the Society of Industrial Microbiology, Orlando, FL, 1990 | 30 | 1990 |
Production of TNFR-Ig D Drapeau, YT Luan, JR Mercer, W Wang, DR Lasko US Patent 7,300,773, 2007 | 20 | 2007 |
Liquid chromatographic isolation of vincristine and vinblastine D Drapeau, HW Blanch, CR Wilke Journal of Chromatography A 390 (2), 297-306, 1987 | 20 | 1987 |
Rationally designed media for cell culture YT Luan, W Wang, R Nolan, D Drapeau US Patent 8,232,075, 2012 | 17 | 2012 |