| Bone recognition mechanism of porcine osteocalcin from crystal structure QQ Hoang, F Sicheri, AJ Howard, DSC Yang Nature 425 (6961), 977-980, 2003 | 641 | 2003 |
| A soluble α-synuclein construct forms a dynamic tetramer W Wang, I Perovic, J Chittuluru, A Kaganovich, LTT Nguyen, J Liao, ... Proceedings of the National Academy of Sciences 108 (43), 17797-17802, 2011 | 571 | 2011 |
| Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein W Wang, LTT Nguyen, C Burlak, F Chegini, F Guo, T Chataway, S Ju, ... Proceedings of the National Academy of Sciences 113 (34), 9587-9592, 2016 | 254 | 2016 |
| Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1 C Das, QQ Hoang, CA Kreinbring, SJ Luchansky, RK Meray, SS Ray, ... Proceedings of the National Academy of Sciences 103 (12), 4675-4680, 2006 | 225 | 2006 |
| Parkinson disease-associated mutation R1441H in LRRK2 prolongs the “active state” of its GTPase domain J Liao, CX Wu, C Burlak, S Zhang, H Sahm, M Wang, ZY Zhang, ... Proceedings of the National Academy of Sciences 111 (11), 4055-4060, 2014 | 136 | 2014 |
| Structure and Specificity of a Quorum-Quenching Lactonase (AiiB) from Agrobacterium tumefaciens, D Liu, PW Thomas, J Momb, QQ Hoang, GA Petsko, D Ringe, W Fast Biochemistry 46 (42), 11789-11799, 2007 | 121 | 2007 |
| Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy F Bassil, PO Fernagut, E Bezard, A Pruvost, T Leste-Lasserre, QQ Hoang, ... Proceedings of the National Academy of Sciences 113 (34), 9593-9598, 2016 | 103 | 2016 |
| Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase MR Landon, RL Lieberman, QQ Hoang, S Ju, JMM Caaveiro, SD Orwig, ... Journal of computer-aided molecular design 23, 491-500, 2009 | 98 | 2009 |
| Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT R Edayathumangalam, R Wu, R Garcia, Y Wang, W Wang, CA Kreinbring, ... Proceedings of the National Academy of Sciences 110 (44), 17820-17825, 2013 | 74 | 2013 |
| Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson disease-associated α-synuclein M Oh, JH Lee, W Wang, HS Lee, WS Lee, C Burlak, W Im, QQ Hoang, ... Proceedings of the National Academy of Sciences 111 (30), 11007-11012, 2014 | 73 | 2014 |
| Zinc coordination geometry and ligand binding affinity: the structural and kinetic analysis of the second-shell serine 228 residue and the methionine 180 residue of the … NJ Ataie, QQ Hoang, MPD Zahniser, Y Tu, A Milne, GA Petsko, D Ringe Biochemistry 47 (29), 7673-7683, 2008 | 48 | 2008 |
| Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA) S Abdeen, T Kunkle, N Salim, AM Ray, N Mammadova, C Summers, ... Journal of medicinal chemistry 61 (16), 7345-7357, 2018 | 40 | 2018 |
| Hydrophilic residues are crucial for ribosomal protein L11 (RPL11) interaction with zinc finger domain of MDM2 and p53 protein activation Q Zhang, H Xiao, SC Chai, QQ Hoang, H Lu Journal of Biological Chemistry 286 (44), 38264-38274, 2011 | 36 | 2011 |
| Discovery and optimization of inhibitors of the Parkinson's disease associated protein DJ-1 S Tashiro, JMM Caaveiro, M Nakakido, A Tanabe, S Nagatoishi, ... ACS Chem Biol., 2018 | 34 | 2018 |
| HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules M Stevens, S Abdeen, N Salim, AM Ray, A Washburn, S Chitre, J Sivinski, ... Bioorganic & medicinal chemistry letters 29 (9), 1106-1112, 2019 | 33 | 2019 |
| Pathway for Parkinson disease QQ Hoang Proceedings of the National Academy of Sciences 111 (7), 2402-2403, 2014 | 29 | 2014 |
| The Parkinson's disease–associated mutation N1437H impairs conformational dynamics in the G domain of LRRK2 X Huang, C Wu, Y Park, X Long, QQ Hoang, J Liao The FASEB Journal 33 (4), 4814, 2019 | 27 | 2019 |
| Hydroxybiphenylamide GroEL/ES Inhibitors Are Potent Antibacterials against Planktonic and Biofilm Forms of Staphylococcus aureus T Kunkle, S Abdeen, N Salim, AM Ray, M Stevens, AJ Ambrose, ... Journal of medicinal chemistry 61 (23), 10651-10664, 2018 | 26 | 2018 |
| Parkinson's disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics CX Wu, J Liao, Y Park, X Reed, VA Engel, NC Hoang, Y Takagi, ... Journal of Biological Chemistry 294 (15), 5907-5913, 2019 | 25 | 2019 |
| Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites CF Liu, GS Brandt, QQ Hoang, N Naumova, V Lazarevic, ES Hwang, ... Proceedings of the National Academy of Sciences 113 (43), E6572-E6581, 2016 | 25 | 2016 |
Greg PetskoProfessor of Neurology, Harvard Medical School and Brigham & Women's HospitalVerified email at bwh.harvard.edu
