| Molecular pathophysiology of Parkinson's disease DJ Moore, AB West, VL Dawson, TM Dawson Annu. Rev. Neurosci. 28, 57-87, 2005 | 1560 | 2005 |
| Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity AB West, DJ Moore, S Biskup, A Bugayenko, WW Smith, CA Ross, ... Proceedings of the National Academy of Sciences 102 (46), 16842-16847, 2005 | 1373 | 2005 |
| A genome-wide linkage and association scan reveals novel loci for autism LA Weiss, DE Arking, ... Nature 461 (7265), 802-808, 2009 | 780 | 2009 |
| Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity AB West, DJ Moore, C Choi, SA Andrabi, X Li, D Dikeman, S Biskup, ... Human molecular genetics 16 (2), 223-232, 2007 | 697 | 2007 |
| Localization of LRRK2 to membranous and vesicular structures in mammalian brain S Biskup, DJ Moore, F Celsi, S Higashi, AB West, SA Andrabi, K Kurkinen, ... Annals of Neurology: Official Journal of the American Neurological …, 2006 | 639 | 2006 |
| Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration WW Smith, Z Pei, H Jiang, DJ Moore, Y Liang, AB West, VL Dawson, ... Proceedings of the National Academy of Sciences 102 (51), 18676-18681, 2005 | 557 | 2005 |
| Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism S Gupta, SE Ellis, FN Ashar, A Moes, JS Bader, J Zhan, AB West, ... Nature communications 5 (1), 5748, 2014 | 530 | 2014 |
| LRRK2 inhibition attenuates microglial inflammatory responses MS Moehle, PJ Webber, T Tse, N Sukar, DG Standaert, TM DeSilva, ... Journal of Neuroscience 32 (5), 1602-1611, 2012 | 484 | 2012 |
| Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease BD Lee, JH Shin, J VanKampen, L Petrucelli, AB West, HS Ko, YI Lee, ... Nature medicine 16 (9), 998-1000, 2010 | 423 | 2010 |
| α-Synuclein gene haplotypes are associated with Parkinson’s disease M Farrer, DM Maraganore, P Lockhart, A Singleton, TG Lesnick, ... Human molecular genetics 10 (17), 1847-1851, 2001 | 420 | 2001 |
| Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape K Day, LL Waite, A Thalacker-Mercer, A West, MM Bamman, JD Brooks, ... Genome biology 14, 1-19, 2013 | 367 | 2013 |
| Parkinson disease and the immune system—associations, mechanisms and therapeutics EK Tan, YX Chao, A West, LL Chan, W Poewe, J Jankovic Nature Reviews Neurology 16 (6), 303-318, 2020 | 299 | 2020 |
| Complex relationship between Parkin mutations and Parkinson disease A West, M Periquet, S Lincoln, CB Lücking, D Nicholl, V Bonifati, N Rawal, ... American journal of medical genetics 114 (5), 584-591, 2002 | 272 | 2002 |
| Formation of α-synuclein Lewy neurite–like aggregates in axons impedes the transport of distinct endosomes LA Volpicelli-Daley, KL Gamble, CE Schultheiss, DM Riddle, AB West, ... Molecular biology of the cell 25 (25), 4010-4023, 2014 | 257 | 2014 |
| LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network Z Liu, N Bryant, R Kumaran, A Beilina, A Abeliovich, MR Cookson, ... Human molecular genetics 27 (2), 385-395, 2018 | 238 | 2018 |
| Abrogation of α-synuclein–mediated dopaminergic neurodegeneration in LRRK2-deficient rats JPL Daher, LA Volpicelli-Daley, JP Blackburn, MS Moehle, AB West Proceedings of the National Academy of Sciences 111 (25), 9289-9294, 2014 | 235 | 2014 |
| Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly (ADP-ribose) polymer-induced cell death SA Andrabi, HC Kang, JF Haince, YI Lee, J Zhang, Z Chi, AB West, ... Nature medicine 17 (6), 692-699, 2011 | 231 | 2011 |
| M1 and M2 immune activation in Parkinson’s disease: foe and ally? MS Moehle, AB West Neuroscience 302, 59-73, 2015 | 223 | 2015 |
| Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization S Sen, PJ Webber, AB West Journal of Biological Chemistry 284 (52), 36346-36356, 2009 | 220 | 2009 |
| Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease CA Da Costa, C Sunyach, E Giaime, A West, O Corti, A Brice, S Safe, ... Nature cell biology 11 (11), 1370-1375, 2009 | 215 | 2009 |
Ted M. DawsonDirector, Institute for Cell Engineering, Professor of Neurology and Neuroscience, JHUSoMVerified email at jhmi.edu
