| Angiogenesis in two animal models of osteoarthritis PI Mapp, PS Avery, DF McWilliams, J Bowyer, C Day, S Moores, ... Osteoarthritis and Cartilage 16 (1), 61-69, 2008 | 118 | 2008 |
| Cathepsin L‐deficient mice exhibit abnormal skin and bone development and show increased resistance to osteoporosis following ovariectomy W Potts, J Bowyer, H Jones, D Tucker, AJ Freemont, A Millest, C Martin, ... International journal of experimental pathology 85 (2), 85-96, 2004 | 100 | 2004 |
| Characterisation of the guinea pig model of osteoarthritis by in vivo three-dimensional magnetic resonance imaging JJ Tessier, J Bowyer, NJ Brownrigg, IS Peers, FR Westwood, JC Waterton, ... Osteoarthritis and cartilage 11 (12), 845-853, 2003 | 94 | 2003 |
| Effects of a metalloproteinase inhibitor on osteochondral angiogenesis, chondropathy and pain behavior in a rat model of osteoarthritis PI Mapp, DA Walsh, J Bowyer, RA Maciewicz Osteoarthritis and cartilage 18 (4), 593-600, 2010 | 81 | 2010 |
| Naphthyl ketones: a new class of Janus kinase 3 inhibitors GR Brown, AM Bamford, J Bowyer, DS James, N Rankine, E Tang, V Torr, ... Bioorganic & medicinal chemistry letters 10 (6), 575-579, 2000 | 62 | 2000 |
| Cathepsin K inhibition reduces CTXII levels and joint pain in the guinea pig model of spontaneous osteoarthritis JJ McDougall, N Schuelert, J Bowyer Osteoarthritis and cartilage 18 (10), 1355-1357, 2010 | 60 | 2010 |
| (1R,2R)-N-(1-Cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): A Potent and Highly … AG Dossetter, H Beeley, J Bowyer, CR Cook, JJ Crawford, JE Finlayson, ... Journal of medicinal chemistry 55 (14), 6363-6374, 2012 | 37 | 2012 |
| Hydantoin based inhibitors of MMP13—discovery of AZD6605 C De Savi, D Waterson, A Pape, S Lamont, E Hadley, M Mills, KM Page, ... Bioorganic & medicinal chemistry letters 23 (16), 4705-4712, 2013 | 25 | 2013 |
| Pharmacokinetic benefits of 3, 4-dimethoxy substitution of a phenyl ring and design of isosteres yielding orally available cathepsin K inhibitors JJ Crawford, PW Kenny, J Bowyer, CR Cook, JE Finlayson, C Heyes, ... Journal of Medicinal Chemistry 55 (20), 8827-8837, 2012 | 25 | 2012 |
| Evaluation of a magnetic resonance biomarker of osteoarthritis disease progression: doxycycline slows tibial cartilage loss in the Dunkin Hartley guinea pig J Bowyer, CG Heapy, JK Flannelly, JC Waterton, RA Maciewicz International journal of experimental pathology 90 (2), 174-181, 2009 | 25 | 2009 |
| Transgenic mice lacking cathepsin L activity. KA Hart, W Potts, J Bowyer, G Slynn, P Elston, W Vernon, D Tucker, ... JOURNAL OF BONE AND MINERAL RESEARCH 11, S366-S366, 1996 | 6 | 1996 |
| Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition AG Dossetter, J Bowyer, CR Cook, JJ Crawford, JE Finlayson, NM Heron, ... Bioorganic & medicinal chemistry letters 22 (17), 5563-5568, 2012 | 5 | 2012 |
| Doxycycline slows MRI-assessed cartilage volume loss in the guinea pig model of osteoarthritis J Tessier, J Bowyer, C Heapy, J Elliott, R Pickford, J Flannelly, ... Proceedings of the International Society for Magnetic Resonance in Medicine …, 2006 | 3 | 2006 |
| In vivo high-resolution three-dimensional magnetic resonance imaging of a rat knee osteoarthritis model induced by meniscal transection YX Wang, FR Westwood, SM Moores, A Ball, C Heapy, R Pickford, ... Proceedings of the International Society for Magnetic Resonance in Medicine …, 2006 | 3 | 2006 |
| Osteoporosis alters the underlying subchondral bone integrity in an experimental model of osteoarthritis in rats R Webster, JK Flannelly, RF Westwood, SJ Read, J Bowyer INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY 90 (1), A79-A80, 2009 | 1 | 2009 |
| 4 NAPROXEN AND A MATRIX METALLOPROTEINASE INHIBITOR BOTH REDUCE WEIGHT BEARING ASYMMETRY, INDICATIVE OF BEHAVIOURAL PAIN, IN THE RAT MENISCAL TRANSECTION MODEL OF OSTEOARTHRITIS J Bowyer, R Webster, R Westwood, C Day, C Stannard, SJ Read, ... Osteoarthritis and Cartilage, C16-C17, 2007 | 1 | 2007 |
| P64 characterisation of temporal changes of aggrecanase-dependant proteoglycan loss in the guinea pig model of spontaneous OA JK Flannelly, CL Day, SJ Read, J Bowyer Osteoarthritis and Cartilage, S48-S49, 2006 | 1 | 2006 |
| Assessing disease modification in the guinea pig model of spontaneous OA J Bowyer, J Tessier, N Brownrigg, R Pickford, R Westwood, J Waterton, ... Trans Orthop Res Soc 28, 759, 2003 | 1 | 2003 |
| 037 THE CATHEPSIN K INHIBITOR AZ12606133 REDUCES ARTICULAR CARTILAGE BREAKDOWN AND JOINT PAIN IN OSTEOARTHRITIC KNEES JJ McDougall, N Schuelert, J Bowyer Osteoarthritis and Cartilage 18, S24-S25, 2010 | | 2010 |
| ASSOCIATION OF OSTEOCHONDRAL ANGIOGENESIS, CARTILAGE LESION AND BEHAVIOURAL PAIN IN A RAT MODEL OF OSTEOARTHRITIS DA Walsh, PI Mapp, R Webster, JJ Bowyer, RA Maciewicz RHEUMATOLOGY 48, I30-I30, 2009 | | 2009 |
