Challenges and Opportunities for Therapeutics Targeting the Voltage-Gated Sodium Channel Isoform NaV1.7 JV Mulcahy, H Pajouhesh, JT Beckley, A Delwig, J Du Bois, JC Hunter Journal of medicinal chemistry 62 (19), 8695-8710, 2019 | 65 | 2019 |
Light evokes melanopsin-dependent vocalization and neural activation associated with aversive experience in neonatal mice A Delwig, AM Logan, DR Copenhagen, AH Ahn Public Library of Science 7 (9), e43787, 2012 | 45 | 2012 |
Kuz and TACE can activate Notch independent of ligand A Delwig, MD Rand Cellular and Molecular Life Sciences 65, 2232-2243, 2008 | 43 | 2008 |
Retinofugal projections from melanopsin-expressing retinal ganglion cells revealed by intraocular injections of Cre-dependent virus A Delwig, DLD Larsen, D Yasumura, CF Yang, NM Shah, ... PLoS One 11 (2), e0149501, 2016 | 38 | 2016 |
Melanopsin expression in the cornea A Delwig, SY Chaney, AS Bertke, J Verweij, S Quirce, DD Larsen, C Yang, ... Visual neuroscience 35, E004, 2018 | 31 | 2018 |
Discovery of a selective, state-independent inhibitor of NaV1.7 by modification of guanidinium toxins H Pajouhesh, JT Beckley, A Delwig, HS Hajare, G Luu, D Monteleone, ... Scientific Reports 10 (1), 14791, 2020 | 29 | 2020 |
The effects of methylmercury on Notch signaling during embryonic neural development in Drosophila melanogaster GL Engel, A Delwig, MD Rand Toxicology in vitro 26 (3), 485-492, 2012 | 29 | 2012 |
Glutamatergic neurotransmission from melanopsin retinal ganglion cells is required for neonatal photoaversion but not adult pupillary light reflex A Delwig, S Majumdar, K Ahern, MM LaVail, R Edwards, TS Hnasko, ... PLoS One 8 (12), e83974, 2013 | 25 | 2013 |
Endocytosis-independent mechanisms of Delta ligand proteolysis A Delwig, C Bland, M Beem-Miller, P Kimberly, MD Rand Experimental cell research 312 (8), 1345-1360, 2006 | 23 | 2006 |
Antinociceptive properties of an isoform-selective inhibitor of Nav1. 7 derived from saxitoxin in mouse models of pain JT Beckley, H Pajouhesh, G Luu, S Klas, A Delwig, D Monteleone, X Zhou, ... Pain 162 (4), 1250-1261, 2021 | 14 | 2021 |
Topical valganciclovir for the treatment of hypertensive anterior uveitis A Delwig, JD Keenan, TP Margolis Cornea 34 (11), 1513-1515, 2015 | 10 | 2015 |
11, 13-modified saxitoxins for the treatment of pain J Mulcahy, H Pajouhesh, GM Shibuya, A Delwig, G Miljanich, J Du Bois US Patent 10,112,953, 2018 | 4 | 2018 |
Discovery of Selective Inhibitors of NaV1.7 Templated on Saxitoxin as Therapeutics for Pain H Pajouhesh, A Delwig, JT Beckley, S Klas, D Monteleone, X Zhou, G Luu, ... ACS Medicinal Chemistry Letters 13 (11), 1763-1768, 2022 | 3 | 2022 |
11, 13-modified saxitoxins for the treatment of pain J Mulcahy, H Pajouhesh, A Delwig, J BECKLEY, GM SHIBUYA, J Du Bois | 3 | 2021 |
11, 13-modified saxitoxins for the treatment of pain J Mulcahy, H Pajouhesh, G Miljanich, A Delwig, J Beckley, GM Shibuya, ... US Patent 11,279,706, 2022 | 2 | 2022 |
11, 13-modified saxitoxins for the treatment of pain J Mulcahy, H Pajouhesh, G Miljanich, A Delwig, J Beckley, GM Shibuya, ... US Patent 11,236,097, 2022 | 2 | 2022 |
Congenital insensitivity to pain: a case report with corneal esthesiometry and in vivo confocal microscopy JD Keenan, JA Gonzales, SG Waxman, A Delwig Cornea 40 (12), 1610-1613, 2021 | 2 | 2021 |
Evaluation of selective NaV1. 7 inhibitors for the treatment of ocular pain A Delwig, H Pajouhesh, D Yeomans, J Du Bois, G Miljanich, J Mulcahy Investigative Ophthalmology & Visual Science 59 (9), 2679-2679, 2018 | 2 | 2018 |
Genetically reconstructed center-surround opponency by targeting channelrhodopsin-2 and halorhodopsin to ganglion cell somata and dendrites KP Greenberg, A Pham, A Delwig, FS Werblin Investigative Ophthalmology & Visual Science 50 (13), 3896-3896, 2009 | 2 | 2009 |
11, 13-modified saxitoxins for the treatment of pain J Mulcahy, H Pajouhesh, GM SHIBUYA, A Delwig, J Dubois, G Miljanich | 1 | 2017 |