| M1 aminopeptidases as drug targets: broad applications or therapeutic niche? N Drinkwater, J Lee, W Yang, TR Malcolm, S McGowan The FEBS journal 284 (10), 1473-1488, 2017 | 86 | 2017 |
| Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors SN Mistry, N Drinkwater, C Ruggeri, KK Sivaraman, S Loganathan, ... Journal of medicinal chemistry 57 (21), 9168-9183, 2014 | 63 | 2014 |
| Human immunoglobulin E flexes between acutely bent and extended conformations N Drinkwater, BP Cossins, AH Keeble, M Wright, K Cain, H Hailu, ... Nature structural & molecular biology 21 (4), 397-404, 2014 | 61 | 2014 |
| Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions N Drinkwater, NB Vinh, SN Mistry, RS Bamert, C Ruggeri, JP Holleran, ... European journal of medicinal chemistry 110, 43-64, 2016 | 59 | 2016 |
| Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors N Drinkwater, H Vu, KM Lovell, KR Criscione, BM Collins, TE Prisinzano, ... Biochemical Journal 431 (1), 51-61, 2010 | 52 | 2010 |
| Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum Aminopeptidases, M1, M17 and M18 A Paiardini, RS Bamert, K Kannan-Sivaraman, N Drinkwater, SN Mistry, ... PloS one 10 (2), e0115859, 2015 | 40 | 2015 |
| Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1, 2, 3, 4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N … GL Grunewald, MR Seim, RC Regier, JL Martin, CL Gee, N Drinkwater, ... Journal of medicinal chemistry 49 (18), 5424-5433, 2006 | 38 | 2006 |
| Missing fragments: detecting cooperative binding in fragment-based drug design PC Nair, AK Malde, N Drinkwater, AE Mark ACS Medicinal Chemistry Letters 3 (4), 322-326, 2012 | 34 | 2012 |
| Cephamycins inhibit pathogen sporulation and effectively treat recurrent Clostridioides difficile infection YN Srikhanta, ML Hutton, MM Awad, N Drinkwater, J Singleton, SL Day, ... Nature microbiology 4 (12), 2237-2245, 2019 | 33 | 2019 |
| Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases NB Vinh, N Drinkwater, TR Malcolm, M Kassiou, L Lucantoni, PM Grin, ... Journal of medicinal chemistry 62 (2), 622-640, 2018 | 32 | 2018 |
| Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity N Drinkwater, CL Gee, M Puri, KR Criscione, MJ McLeish, GL Grunewald, ... Biochemical Journal 422 (3), 463-471, 2009 | 28 | 2009 |
| From crystal to compound: structure-based antimalarial drug discovery N Drinkwater, S McGowan Biochemical Journal 461 (3), 349-369, 2014 | 26 | 2014 |
| Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate RAV Morales, CA MacRaild, J Seow, B Krishnarjuna, N Drinkwater, ... Scientific reports 5 (1), 10103, 2015 | 25 | 2015 |
| M17 aminopeptidases diversify function by moderating their macromolecular assemblies and active site environment N Drinkwater, TR Malcolm, S McGowan Biochimie 166, 38-51, 2019 | 24 | 2019 |
| Identification and validation of a potent dual inhibitor of the P. falciparum M1 and M17 aminopeptidases using virtual screening C Ruggeri, N Drinkwater, KK Sivaraman, RS Bamert, S McGowan, ... PLoS One 10 (9), e0138957, 2015 | 24 | 2015 |
| Enzyme adaptation to inhibitor binding: A cryptic binding site in phenylethanolamine N-methyltransferase CL Gee*, N Drinkwater*, JDA Tyndall, GL Grunewald, Q Wu, MJ McLeish, ... Journal of medicinal chemistry 50 (20), 4845-4853, 2007 | 23 | 2007 |
| Circumventing the stability-function trade-off in an engineered FN3 domain BT Porebski, PJ Conroy, N Drinkwater, P Schofield, R Vazquez-Lombardi, ... Protein Engineering, Design and Selection 29 (11), 541-550, 2016 | 21 | 2016 |
| Structure–activity studies of β-hairpin peptide inhibitors of the Plasmodium falciparum AMA1–RON2 interaction G Wang, N Drinkwater, DR Drew, CA MacRaild, DK Chalmers, B Mohanty, ... Journal of Molecular Biology 428 (20), 3986-3998, 2016 | 21 | 2016 |
| Novel human aminopeptidase N inhibitors: Discovery and optimization of subsite binding interactions J Lee, NB Vinh, N Drinkwater, W Yang, K Kannan Sivaraman, ... Journal of Medicinal Chemistry 62 (15), 7185-7209, 2019 | 18 | 2019 |
| X‐ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti‐malarial drug targets PfA‐M1 and PfA‐M17 N Drinkwater, RS Bamert, KK Sivaraman, A Paiardini, S McGowan Proteins: Structure, Function, and Bioinformatics 83 (4), 789-795, 2015 | 15 | 2015 |
Sheena McGowanMonash UniversityVerified email at monash.edu
Sheena McGowanMonash UniversityVerified email at monash.edu