|Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function|
L Chen, SN Willis, A Wei, BJ Smith, JI Fletcher, MG Hinds, PM Colman, ...
Molecular cell 17 (3), 393-403, 2005
|The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized|
MF Van Delft, AH Wei, KD Mason, CJ Vandenberg, L Chen, PE Czabotar, ...
Cancer cell 10 (5), 389-399, 2006
|HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins|
AM Verhagen, J Silke, PG Ekert, M Pakusch, H Kaufmann, LM Connolly, ...
Journal of Biological Chemistry 277 (1), 445-454, 2002
|Structural insights into the degradation of Mcl-1 induced by BH3 domains|
PE Czabotar, EF Lee, MF van Delft, CL Day, BJ Smith, DCS Huang, ...
Proceedings of the National Academy of Sciences 104 (15), 6217-6222, 2007
|Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans|
K Linke, PD Mace, CA Smith, DL Vaux, J Silke, CL Day
Cell death & differentiation 15 (5), 841-848, 2008
|The Bcl-2-regulated apoptotic pathway|
S Willis, CL Day, MG Hinds, DCS Huang
Journal of cell science 116 (20), 4053-4056, 2003
|Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands|
CL Day, L Chen, SJ Richardson, PJ Harrison, DCS Huang, MG Hinds
Journal of Biological Chemistry 280 (6), 4738-4744, 2005
|Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat|
MG Hinds, RS Norton, DL Vaux, CL Day
Nature structural biology 6 (7), 648-651, 1999
|Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets|
MG Hinds, C Smits, R Fredericks-Short, JM Risk, M Bailey, DCS Huang, ...
Cell Death & Differentiation 14 (1), 128-136, 2007
|TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (TNF) to efficiently activate NF-κB and to prevent TNF-induced apoptosis|
JE Vince, D Pantaki, R Feltham, PD Mace, SM Cordier, AC Schmukle, ...
Journal of Biological Chemistry 284 (51), 35906-35915, 2009
|Bak activation for apoptosis involves oligomerization of dimers via their α6 helices|
G Dewson, T Kratina, P Czabotar, CL Day, JM Adams, RM Kluck
Molecular cell 36 (4), 696-703, 2009
|Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1|
CL Day, C Smits, FC Fan, EF Lee, WD Fairlie, MG Hinds
Journal of molecular biology 380 (5), 958-971, 2008
|The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity|
MG Hinds, M Lackmann, GL Skea, PJ Harrison, DCS Huang, CL Day
The EMBO journal 22 (7), 1497-1507, 2003
|Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance|
J Silke, T Kratina, D Chu, PG Ekert, CL Day, M Pakusch, DCS Huang, ...
Proceedings of the National Academy of Sciences 102 (45), 16182-16187, 2005
|RINGs hold the key to ubiquitin transfer|
R Budhidarmo, Y Nakatani, CL Day
Trends in biochemical sciences 37 (2), 58-65, 2012
|Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment|
PD Mace, K Linke, R Feltham, FR Schumacher, CA Smith, DL Vaux, ...
Journal of Biological Chemistry 283 (46), 31633-31640, 2008
|The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3–and caspase 9–interacting sites|
J Silke, CJ Hawkins, PG Ekert, J Chew, CL Day, M Pakusch, ...
The Journal of cell biology 157 (1), 115-124, 2002
|Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization|
R Feltham, B Bettjeman, R Budhidarmo, PD Mace, S Shirley, SM Condon, ...
Journal of Biological Chemistry 286 (19), 17015-17028, 2011
|Birinapant, a smac-mimetic with improved tolerability for the treatment of solid tumors and hematological malignancies|
SM Condon, Y Mitsuuchi, Y Deng, MG LaPorte, SR Rippin, T Haimowitz, ...
Journal of medicinal chemistry 57 (9), 3666-3677, 2014
|Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP|
J Silke, PG Ekert, CL Day, CJ Hawkins, M Baca, J Chew, M Pakusch, ...
The EMBO journal 20 (12), 3114-3123, 2001