|RNAi therapeutics: principles, prospects and challenges|
L Aagaard, JJ Rossi
Advanced drug delivery reviews 59 (2-3), 75-86, 2007
|Distance constraints between microRNA target sites dictate efficacy and cooperativity|
P Sætrom, BSE Heale, O Snøve Jr, L Aagaard, J Alluin, JJ Rossi
Nucleic acids research 35 (7), 2333-2342, 2007
|The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells|
MS Weinberg, LM Villeneuve, A Ehsani, M Amarzguioui, L Aagaard, ...
Rna 12 (2), 256-262, 2006
|Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC|
D Castanotto, K Sakurai, R Lingeman, H Li, L Shively, L Aagaard, H Soifer, ...
Nucleic acids research 35 (15), 5154-5164, 2007
|Identification of endogenous retroviral reading frames in the human genome|
P Villesen, L Aagaard, C Wiuf, FS Pedersen
Retrovirology 1 (1), 32, 2004
|B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivity|
T Brudek, T Christensen, L Aagaard, T Petersen, HJ Hansen, ...
Retrovirology 6 (1), 1-13, 2009
|A facile lentiviral vector system for expression of doxycycline-inducible shRNAs: knockdown of the pre-miRNA processing enzyme Drosha|
L Aagaard, M Amarzguioui, G Sun, LC Santos, A Ehsani, H Prydz, ...
Molecular Therapy 15 (5), 938-945, 2007
|Mesenchymal stem cells derived from human induced pluripotent stem cells retain adequate osteogenicity and chondrogenicity but less adipogenicity|
R Kang, Y Zhou, S Tan, G Zhou, L Aagaard, L Xie, C Bünger, L Bolund, ...
Stem cell research & therapy 6 (1), 1-14, 2015
|Molecular mechanisms in DM1—a focus on foci|
OJ Pettersson, L Aagaard, TG Jensen, CK Damgaard
Nucleic acids research 43 (4), 2433-2441, 2015
|DDX6 regulates sequestered nuclear CUG-expanded DMPK-mRNA in dystrophia myotonica type 1|
OJ Pettersson, L Aagaard, D Andrejeva, R Thomsen, TG Jensen, ...
Nucleic acids research 42 (11), 7186-7200, 2014
|Enhanced genome editing in mammalian cells with a modified dual-fluorescent surrogate system|
Y Zhou, Y Liu, D Hussmann, P Brøgger, RA Al-Saaidi, S Tan, L Lin, ...
Cellular and Molecular Life Sciences 73 (13), 2543-2563, 2016
|Adeno‐associated virus‐delivered polycistronic microRNA‐clusters for knockdown of vascular endothelial growth factor in vivo|
M Pihlmann, AL Askou, L Aagaard, GH Bruun, JD Svalgaard, ...
The journal of gene medicine 14 (5), 328-338, 2012
|Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution|
AL Kjeldbjerg, P Villesen, L Aagaard, FS Pedersen
BMC Evolutionary Biology 8 (1), 1-11, 2008
|Multigenic lentiviral vectors for combined and tissue-specific expression of miRNA-and protein-based antiangiogenic factors|
AL Askou, L Aagaard, C Kostic, Y Arsenijevic, AK Hollensen, T Bek, ...
Molecular Therapy-Methods & Clinical Development 2, 14064, 2015
|Rational design of micro-RNA-like bifunctional siRNAs targeting HIV and the HIV coreceptor CCR5|
A Ehsani, P Saetrom, J Zhang, J Alluin, H Li, O Snøve Jr, L Aagaard, ...
Molecular Therapy 18 (4), 796-802, 2010
|Fv1-like restriction of N-tropic replication-competent murine leukaemia viruses in mCAT-1-expressing human cells|
L Aagaard, JG Mikkelsen, S Warming, M Duch, FS Pedersen
Journal of general virology 83 (2), 439-442, 2002
|The∼ 30-million-year-old ERVPb1 envelope gene is evolutionarily conserved among hominoids and Old World monkeys|
L Aagaard, P Villesen, AL Kjeldbjerg, FS Pedersen
Genomics 86 (6), 685-691, 2005
|An RNA secondary structure bias for non‐homologous reverse transcriptase‐mediated deletions in vivo|
M Duch, ML Carrasco, T Jespersen, L Aagaard, FS Pedersen
Nucleic acids research 32 (6), 2039-2048, 2004
|Efficient replication of full-length murine leukemia viruses modified at the dimer initiation site regions|
L Aagaard, SV Rasmussen, JG Mikkelsen, FS Pedersen
Virology 318 (1), 360-370, 2004
|Suppression of choroidal neovascularization by AAV-based dual-acting antiangiogenic gene therapy|
AL Askou, S Alsing, JNE Benckendorff, A Holmgaard, JG Mikkelsen, ...
Molecular Therapy-Nucleic Acids 16, 38-50, 2019