| Oncogenic protein interfaces: small molecules, big challenges TL Nero, CJ Morton, JK Holien, J Wielens, MW Parker Nature Reviews Cancer 14 (4), 248-262, 2014 | 363 | 2014 |
| The GM–CSF/IL‐3/IL‐5 cytokine receptor family: from ligand recognition to initiation of signaling SE Broughton, U Dhagat, TR Hercus, TL Nero, MA Grimbaldeston, ... Immunological reviews 250 (1), 277-302, 2012 | 262 | 2012 |
| Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites D Braig, TL Nero, HG Koch, B Kaiser, X Wang, JR Thiele, CJ Morton, ... Nature communications 8 (1), 14188, 2017 | 207 | 2017 |
| Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA DB Ascher, J Wielens, TL Nero, L Doughty, CJ Morton, MW Parker Scientific reports 4 (1), 4765, 2014 | 139 | 2014 |
| Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators U Flierl, TL Nero, B Lim, JF Arthur, Y Yao, SM Jung, E Gitz, AY Pollitt, ... Journal of Experimental Medicine 212 (2), 129-137, 2015 | 127 | 2015 |
| Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia MR Morrow, B Batchuluun, J Wu, E Ahmadi, JM Leroux, ... Cell Metabolism 34 (6), 919-936. e8, 2022 | 113 | 2022 |
| Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms SL Pinkosky, JW Scott, EM Desjardins, BK Smith, EA Day, RJ Ford, ... Nature metabolism 2 (9), 873-881, 2020 | 112 | 2020 |
| Signalling by the βc family of cytokines TR Hercus, U Dhagat, WLT Kan, SE Broughton, TL Nero, M Perugini, ... Cytokine & growth factor reviews 24 (3), 189-201, 2013 | 105 | 2013 |
| Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs) CJ Burns, DG Bourke, L Andrau, X Bu, SA Charman, AC Donohue, ... Bioorganic & medicinal chemistry letters 19 (20), 5887-5892, 2009 | 88 | 2009 |
| The βc receptor family–Structural insights and their functional implications SE Broughton, TL Nero, U Dhagat, WL Kan, TR Hercus, D Tvorogov, ... Cytokine 74 (2), 247-258, 2015 | 87 | 2015 |
| Repurposing of drugs as STAT3 inhibitors for cancer therapy PS Thilakasiri, RS Dmello, TL Nero, MW Parker, M Ernst, AL Chand Seminars in cancer biology 68, 31-46, 2021 | 85 | 2021 |
| Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription D Thomas, JA Powell, F Vergez, DH Segal, NYN Nguyen, A Baker, ... Blood, The Journal of the American Society of Hematology 122 (5), 738-748, 2013 | 79 | 2013 |
| Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8α and C9 SE Wickham, EM Hotze, AJ Farrand, G Polekhina, TL Nero, S Tomlinson, ... Journal of Biological Chemistry 286 (23), 20952-20962, 2011 | 75 | 2011 |
| Small molecule binding to Alzheimer risk factor CD33 promotes Aβ phagocytosis LA Miles, SJ Hermans, GAN Crespi, JH Gooi, L Doughty, TL Nero, ... Iscience 19, 110-118, 2019 | 61 | 2019 |
| Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody SE Broughton, TR Hercus, MP Hardy, BJ McClure, TL Nero, M Dottore, ... Cell reports 8 (2), 410-419, 2014 | 56 | 2014 |
| C-reactive protein, immunothrombosis and venous thromboembolism C Dix, J Zeller, H Stevens, SU Eisenhardt, KSCT Shing, TL Nero, ... Frontiers in Immunology 13, 1002652, 2022 | 50 | 2022 |
| Evaluating the benefits of renin-angiotensin system inhibitors as cancer treatments MV Perini, RS Dmello, TL Nero, AL Chand Pharmacology & therapeutics 211, 107527, 2020 | 49 | 2020 |
| Conformational changes in the GM-CSF receptor suggest a molecular mechanism for affinity conversion and receptor signaling SE Broughton, TR Hercus, TL Nero, M Dottore, BJ McClure, U Dhagat, ... Structure 24 (8), 1271-1281, 2016 | 49 | 2016 |
| Role of the β Common (βc) Family of Cytokines in Health and Disease TR Hercus, WLT Kan, SE Broughton, D Tvorogov, HS Ramshaw, ... Cold Spring Harbor Perspectives in Biology 10 (6), a028514, 2018 | 48 | 2018 |
| Lysophosphatidylcholine is a major component of platelet microvesicles promoting platelet activation and reporting atherosclerotic plaque instability P Diehl, F Nienaber, MTK Zaldivia, J Stamm, PM Siegel, NA Mellett, ... Thrombosis and Haemostasis 119 (08), 1295-1310, 2019 | 45 | 2019 |
