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Wessel  A C Burger
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Year
Crystal structure of the M5 muscarinic acetylcholine receptor
Z Vuckovic, PR Gentry, AE Berizzi, K Hirata, S Varghese, G Thompson, ...
Proceedings of the National Academy of Sciences 116 (51), 26001-26007, 2019
702019
Toward an understanding of the structural basis of allostery in muscarinic acetylcholine receptors
WAC Burger, PM Sexton, A Christopoulos, DM Thal
Journal of General Physiology 150 (10), 1360-1372, 2018
492018
Structure–Affinity Relationships and Structure–Kinetics Relationships of Pyrido[2,1-f]purine-2,4-dione Derivatives as Human Adenosine A3 Receptor Antagonists
L Xia, WAC Burger, JPD van Veldhoven, BJ Kuiper, TT van Duijl, ...
Journal of Medicinal Chemistry 60 (17), 7555-7568, 2017
292017
Structural basis of efficacy-driven ligand selectivity at GPCRs
AS Powers, V Pham, WAC Burger, G Thompson, Y Laloudakis, ...
Nature Chemical Biology 19 (7), 805-814, 2023
212023
Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics
Z Vuckovic, J Wang, V Pham, JI Mobbs, MJ Belousoff, A Bhattarai, ...
Elife 12, e83477, 2023
92023
6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity
M Jorg, ET van der Westhuizen, E Khajehali, WAC Burger, JM White, ...
ACS Chemical Neuroscience 10 (3), 1099-1114, 2018
82018
Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors
JI Mobbs, KA Black, M Tran, WAC Burger, H Venugopal, TR Holman, ...
Blood 142 (14), 1233-1242, 2023
72023
Identification of a Novel Allosteric Site at the M5 Muscarinic Acetylcholine Receptor
WAC Burger, PR Gentry, AE Berizzi, Z Vuckovic, ET Van Der Westhuizen, ...
ACS Chemical Neuroscience 12 (16), 3112-3123, 2021
72021
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR
WAC Burger, V Pham, Z Vuckovic, AS Powers, JI Mobbs, Y Laloudakis, ...
Nature communications 14 (1), 5440, 2023
62023
Importance of receptor expression in the classification of novel ligands at the M2 muscarinic acetylcholine receptor
Y Jiang, M Yeasmin, AB Gondin, A Christopoulos, C Valant, WAC Burger, ...
British Journal of Pharmacology, 2023
62023
Recessive CHRM5 variant as a potential cause of neurogenic bladder
S Schneider, L Schierbaum, WAC Burger, S Seltzsam, C Wang, B Zheng, ...
American Journal of Medical Genetics Part A 191 (8), 2083-2091, 2023
12023
Positive allosteric modulation of a GPCR ternary complex
W Burger, C Draper-Joyce, C Valant, A Christopoulos, DM Thal
bioRxiv, 2024.04. 04.588200, 2024
2024
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Articles 1–12