Crystal structure of the M5 muscarinic acetylcholine receptor Z Vuckovic, PR Gentry, AE Berizzi, K Hirata, S Varghese, G Thompson, ... Proceedings of the National Academy of Sciences 116 (51), 26001-26007, 2019 | 70 | 2019 |
Toward an understanding of the structural basis of allostery in muscarinic acetylcholine receptors WAC Burger, PM Sexton, A Christopoulos, DM Thal Journal of General Physiology 150 (10), 1360-1372, 2018 | 49 | 2018 |
Structure–Affinity Relationships and Structure–Kinetics Relationships of Pyrido[2,1-f]purine-2,4-dione Derivatives as Human Adenosine A3 Receptor Antagonists L Xia, WAC Burger, JPD van Veldhoven, BJ Kuiper, TT van Duijl, ... Journal of Medicinal Chemistry 60 (17), 7555-7568, 2017 | 29 | 2017 |
Structural basis of efficacy-driven ligand selectivity at GPCRs AS Powers, V Pham, WAC Burger, G Thompson, Y Laloudakis, ... Nature Chemical Biology 19 (7), 805-814, 2023 | 21 | 2023 |
Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics Z Vuckovic, J Wang, V Pham, JI Mobbs, MJ Belousoff, A Bhattarai, ... Elife 12, e83477, 2023 | 9 | 2023 |
6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity M Jorg, ET van der Westhuizen, E Khajehali, WAC Burger, JM White, ... ACS Chemical Neuroscience 10 (3), 1099-1114, 2018 | 8 | 2018 |
Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors JI Mobbs, KA Black, M Tran, WAC Burger, H Venugopal, TR Holman, ... Blood 142 (14), 1233-1242, 2023 | 7 | 2023 |
Identification of a Novel Allosteric Site at the M5 Muscarinic Acetylcholine Receptor WAC Burger, PR Gentry, AE Berizzi, Z Vuckovic, ET Van Der Westhuizen, ... ACS Chemical Neuroscience 12 (16), 3112-3123, 2021 | 7 | 2021 |
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR WAC Burger, V Pham, Z Vuckovic, AS Powers, JI Mobbs, Y Laloudakis, ... Nature communications 14 (1), 5440, 2023 | 6 | 2023 |
Importance of receptor expression in the classification of novel ligands at the M2 muscarinic acetylcholine receptor Y Jiang, M Yeasmin, AB Gondin, A Christopoulos, C Valant, WAC Burger, ... British Journal of Pharmacology, 2023 | 6 | 2023 |
Recessive CHRM5 variant as a potential cause of neurogenic bladder S Schneider, L Schierbaum, WAC Burger, S Seltzsam, C Wang, B Zheng, ... American Journal of Medical Genetics Part A 191 (8), 2083-2091, 2023 | 1 | 2023 |
Positive allosteric modulation of a GPCR ternary complex W Burger, C Draper-Joyce, C Valant, A Christopoulos, DM Thal bioRxiv, 2024.04. 04.588200, 2024 | | 2024 |