Integrating artificial with natural cells to translate chemical messages that direct E. coli behaviour R Lentini, SP Santero, F Chizzolini, D Cecchi, J Fontana, M Marchioretto, ... Nature communications 5 (1), 4012, 2014 | 265 | 2014 |
Two-way chemical communication between artificial and natural cells R Lentini, NY Martín, M Forlin, L Belmonte, J Fontana, M Cornella, ... ACS central science 3 (2), 117-123, 2017 | 197 | 2017 |
Synthetic CRISPR-Cas gene activators for transcriptional reprogramming in bacteria C Dong, J Fontana, A Patel, JM Carothers, JG Zalatan Nature communications 9 (1), 1-11, 2018 | 191 | 2018 |
Synthetic CRISPR-Cas gene activators for transcriptional reprogramming in bacteria C Dong, J Fontana, A Patel, JM Carothers, JG Zalatan Nature communications 9 (1), 1-11, 2018 | 191 | 2018 |
Effective CRISPRa-mediated control of gene expression in bacteria must overcome strict target site requirements J Fontana, C Dong, C Kiattisewee, VP Chavali, BI Tickman, JM Carothers, ... Nature Communications 11 (1), 1618, 2020 | 79 | 2020 |
Regulated Expression of sgRNAs Tunes CRISPRi in E. coli J Fontana, C Dong, JY Ham, JG Zalatan, JM Carothers Biotechnology Journal 13 (9), 1800069, 2018 | 56 | 2018 |
Challenges and opportunities with CRISPR activation in bacteria for data-driven metabolic engineering J Fontana, D Sparkman-Yager, JG Zalatan, JM Carothers Current Opinion in Biotechnology 64, 190-198, 2020 | 37 | 2020 |
Portable bacterial CRISPR transcriptional activation enables metabolic engineering in Pseudomonas putida C Kiattisewee, C Dong, J Fontana, W Sugianto, P Peralta-Yahya, ... Metabolic engineering 66, 283-295, 2021 | 33 | 2021 |
Multi-layer CRISPRa/i circuits for dynamic genetic programs in cell-free and bacterial systems BI Tickman, DA Burbano, VP Chavali, C Kiattisewee, J Fontana, ... Cell Systems 13 (3), 215-229. e8, 2022 | 18 | 2022 |
Prospects for engineering dynamic CRISPR–Cas transcriptional circuits to improve bioproduction J Fontana, WE Voje, JG Zalatan, JM Carothers Journal of Industrial Microbiology and Biotechnology 45 (7), 481-490, 2018 | 18 | 2018 |
Complex dependence of CRISPR-Cas9 binding strength on guide RNA spacer lengths A Khakimzhan, D Garenne, B Tickman, J Fontana, J Carothers, ... Physical Biology 18 (5), 056003, 2021 | 6 | 2021 |
Guide RNA structure design enables combinatorial CRISPRa programs for biosynthetic profiling J Fontana, D Sparkman-Yager, I Faulkner, R Cardiff, C Kiattisewee, ... bioRxiv, 2023.11. 17.567465, 2023 | 1 | 2023 |
Modular kinetically-controlled functional rna constructs and related compositions, systems, and methods JM Carothers, J Zalatan, D Sparkman-Yager, J Fontana US Patent App. 18/260,305, 2024 | | 2024 |
Genetic manipulation method in bacteria C Kiattisewee, JM Carothers, J Zalatan, ID Faulkner, J Fontana, C Dong US Patent App. 18/306,960, 2023 | | 2023 |
Proofreading mechanism of Class 2 CRISPR-Cas systems A Khakimzhan, D Garenne, BI Tickman, J Fontana, J Carothers, ... arXiv preprint arXiv:2004.09237, 2020 | | 2020 |
CRISPR-Cas activation for regulating multi-gene expression in bacteria J Fontana University of Washington, 2020 | | 2020 |
Engineering E. coli to reduce sulfate aerobically J Fontana | | 2011 |