Charles D Cox
Charles D Cox
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Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension
CD Cox, C Bae, L Ziegler, S Hartley, V Nikolova-Krstevski, PR Rohde, ...
Nature communications 7 (1), 10366, 2016
Piezo1 channels are inherently mechanosensitive
R Syeda, MN Florendo, CD Cox, JM Kefauver, JS Santos, B Martinac, ...
Cell reports 17 (7), 1739-1746, 2016
Biophysical principles of ion-channel-mediated mechanosensory transduction
CD Cox, N Bavi, B Martinac
Cell Reports 29 (1), 1-12, 2019
Bacterial mechanosensors
CD Cox, N Bavi, B Martinac
Annual review of physiology 80, 71-93, 2018
Mammalian TRP ion channels are insensitive to membrane stretch
Y Nikolaev, CD Cox, P Ridone, PR Rohde, JF Cordero-Morales, ...
Biophysical Journal 118 (3), 22a, 2020
Bacterial metabolic ‘toxins’: a new mechanism for lactose and food intolerance, and irritable bowel syndrome
AK Campbell, SB Matthews, N Vassel, CD Cox, R Naseem, J Chaichi, ...
Toxicology 278 (3), 268-276, 2010
Disruption of membrane cholesterol organization impairs the activity of PIEZO1 channel clusters
P Ridone, E Pandzic, M Vassalli, CD Cox, A Macmillan, PA Gottlieb, ...
Journal of General Physiology 152 (8), e201912515, 2020
Selectivity mechanism of the mechanosensitive channel MscS revealed by probing channel subconducting states
CD Cox, T Nomura, CS Ziegler, AK Campbell, KT Wann, B Martinac
Nature communications 4 (1), 2137, 2013
Origin of the force: the force-from-lipids principle applied to piezo channels
CD Cox, N Bavi, B Martinac
Current topics in membranes 79, 59-96, 2017
Visualization of the mechanosensitive ion channel MscS under membrane tension
Y Zhang, C Daday, RX Gu, CD Cox, B Martinac, BL de Groot, T Walz
Nature 590 (7846), 509-514, 2021
The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels
N Bavi, DM Cortes, CD Cox, PR Rohde, W Liu, JW Deitmer, O Bavi, ...
Nature communications 7 (1), 11984, 2016
Influence of global and local membrane curvature on mechanosensitive ion channels: a finite element approach
O Bavi, CD Cox, M Vossoughi, R Naghdabadi, Y Jamali, B Martinac
Membranes 6 (1), 14, 2016
Force-and cell state–dependent recruitment of Piezo1 drives focal adhesion dynamics and calcium entry
M Yao, A Tijore, D Cheng, JV Li, A Hariharan, B Martinac, ...
Science advances 8 (45), eabo1461, 2022
Biophysical implications of lipid bilayer rheometry for mechanosensitive channels
N Bavi, Y Nakayama, O Bavi, CD Cox, QH Qin, B Martinac
Proceedings of the National Academy of Sciences 111 (38), 13864-13869, 2014
Piezo1 forms specific, functionally important interactions with phosphoinositides and cholesterol
A Buyan, CD Cox, J Barnoud, J Li, HSM Chan, B Martinac, SJ Marrink, ...
Biophysical journal 119 (8), 1683-1697, 2020
The evolutionary ‘tinkering’of MscS-like channels: generation of structural and functional diversity
CD Cox, Y Nakayama, T Nomura, B Martinac
Pflügers Archiv-European Journal of Physiology 467, 3-13, 2015
Mechanosensing by Piezo1 and its implications for physiology and various pathologies
A Lai, CD Cox, N Chandra Sekar, P Thurgood, A Jaworowski, K Peter, ...
Biological Reviews 97 (2), 604-614, 2022
Mechanosensory transduction: focus on ion channels
B Martinac, CD Cox
Reference Module in Life Sciences; Elsevier: Amsterdam, The Netherlands …, 2017
TMEM87a/Elkin1, a component of a novel mechanoelectrical transduction pathway, modulates melanoma adhesion and migration
A Patkunarajah, JH Stear, M Moroni, L Schroeter, J Blaszkiewicz, ...
Elife 9, e53308, 2020
Cell membrane mechanics and mechanosensory transduction
B Martinac, YA Nikolaev, G Silvani, N Bavi, V Romanov, Y Nakayama, ...
Current Topics in Membranes 86, 83-141, 2020
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